Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors
Author:
Affiliation:
1. Departments of Medicinal Chemistry, ‡Internal Medicine, §Pharmacology, and ∥Biological Chemistry, ⊥Life Sciences Institute, and #Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States
Funder
National Cancer Institute
Prostate Cancer Foundation
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00613
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1. Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
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5. Reactivation of Latent HIV-1 by Inhibition of BRD4
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