Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition-Reference-Cited by-同舟云学术

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

Published:2015-04-30 Issue:4 Volume:59 Page:1425-1439
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Theodoulou Natalie H.¹²,Bamborough Paul³,Bannister Andrew J.⁴,Becher Isabelle⁵,Bit Rino A.¹,Che Ka Hing⁴,Chung Chun-wa³,Dittmann Antje⁵,Drewes Gerard⁵,Drewry David H.⁶,Gordon Laurie⁷,Grandi Paola⁵,Leveridge Melanie⁷,Lindon Matthew¹,Michon Anne-Marie⁵,Molnar Judit¹,Robson Samuel C.⁴,Tomkinson Nicholas C. O.²,Kouzarides Tony⁴,Prinjha Rab K.¹,Humphreys Philip G.¹

Affiliation:

1. Epinova Discovery Performance Unit, GlaxoSmithKline R&D, Stevenage, Hertfordshire SG1 2NY, U.K.

2. WestCHEM, Department of Pure and Applied Chemistry, Thomas Graham Building, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, U.K.

3. Computational & Structural Chemistry, Molecular Discovery Research, GlaxoSmithKline R&D, Stevenage, Hertfordshire SG1 2NY, U.K.

4. Department of Pathology, Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, U.K.

5. Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline R&D, Meyerhofstrasse 1, 69117 Heidelberg, Germany

6. Department of Chemical Biology, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, United States

7. Biological Sciences, Molecular Discovery Research, GlaxoSmithKline R&D, Stevenage, Hertfordshire SG1 2NY, U.K.

Funder

GlaxoSmithKline

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00256

Reference68 articles.

1. OPERating ON Chromatin, a Colorful Language where Context Matters

2. Small Molecule Bromodomain Inhibitors

3. Structure and acetyl-lysine recognition of the bromodomain

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