Structure–Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines

Author:

Gonzàlez Cabrera Diego1,Douelle Frederic1,Le Manach Claire1,Han Ze1,Paquet Tanya1,Taylor Dale2,Njoroge Mathew2,Lawrence Nina2,Wiesner Lubbe23,Waterson David4,Witty Michael J.4,Wittlin Sergio56,Street Leslie J.1,Chibale Kelly137

Affiliation:

1. Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa

2. Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa

3. Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, Cape Town 7701, South Africa

4. Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, P.O. Box 1826, 1215 Geneva, Switzerland

5. Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland

6. University of Basel, 4002 Basel, Switzerland

7. South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch, Cape Town 7701, South Africa

Funder

South African Medical Research Council

Medicines for Malaria Venture

Department of Science and Technology, Republic of South Africa

University of Capetown

Technology Innovation Agency

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference21 articles.

1. WHO. World MalariaReport 2013. http://www.who.int/malaria/publications/world_malaria_report_2013/report/en/(accessed February 30, 2015) .

2. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

3. The pathogenic basis of malaria

4. The State of the Art in Anti-Malarial Drug Discovery and Development

5. Novel Approaches to Antimalarial Drug Discovery

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