Discovery of Small Molecules for Up-Regulating the Translation of Antiamyloidogenic Secretase, a Disintegrin and Metalloproteinase 10 (ADAM10), by Binding to the G-Quadruplex-Forming Sequence in the 5′ Untranslated Region (UTR) of Its mRNA-Reference-Cited by-同舟云学术

Discovery of Small Molecules for Up-Regulating the Translation of Antiamyloidogenic Secretase, a Disintegrin and Metalloproteinase 10 (ADAM10), by Binding to the G-Quadruplex-Forming Sequence in the 5′ Untranslated Region (UTR) of Its mRNA

Published:2015-04-15 Issue:9 Volume:58 Page:3875-3891
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dai Jie¹,Liu Zhen-Quan¹,Wang Xiao-Qin¹,Lin Jing¹,Yao Pei-Fen¹,Huang Shi-Liang¹,Ou Tian-Miao¹,Tan Jia-Heng¹,Li Ding¹,Gu Lian-Quan¹,Huang Zhi-Shu¹

Affiliation:

1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People’s Republic of China

Funder

Ministry of Education of the People's Republic of China

National Natural Science Foundation of China

Guangdong Provincial Key Laboratory of Construction Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00139

Reference49 articles.

1. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

2. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

3. Memory-enhancing effects of secreted forms of the -amyloid precursor protein in normal and amnestic mice

4. Increased Activity-Regulating and Neuroprotective Efficacy of α-Secretase-Derived Secreted Amyloid Precursor Protein Conferred by a C-Terminal Heparin-Binding Domain

5. Alpha-Secretase As a Therapeutic Target

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