Discovery of Orally Bioavailable and Brain-Penetrable Prodrugs of the Potent nSMase2 Inhibitor DPTIP-Reference-Cited by-同舟云学术

Discovery of Orally Bioavailable and Brain-Penetrable Prodrugs of the Potent nSMase2 Inhibitor DPTIP

Published:2022-08-05 Issue:16 Volume:65 Page:11111-11125
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pal Arindom¹²^ORCID,Gori Sadakatali¹²,Yoo Seung-wan¹,Thomas Ajit G.²,Wu Ying²,Friedman Jacob²,Tenora Lukáš¹²,Bhasin Harshit¹²,Alt Jesse²,Haughey Norman¹³,Slusher Barbara S.¹²³⁴⁵^ORCID,Rais Rana¹²⁴^ORCID

Affiliation:

1. Department of Neurology, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States

2. Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States

3. Departments of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States

4. Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States

5. Department of Oncology, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States

Funder

Alzheimer's Association

National Institute on Aging

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00562

Reference62 articles.

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4. Cambinol, a Novel Inhibitor of Neutral Sphingomyelinase 2 Shows Neuroprotective Properties

5. Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi

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