Design and Synthesis of Fibroblast Growth Factor Receptor (FGFR) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Cancer

Author:

Wan Guoquan1,Feng Zhanzhan1,Zhang Qiangsheng1,Li Xiao1,Ran Kai2,Feng Huan1,Luo Tianwen1,Zhou Shuyan1,Su Chang1,Wei Wei1,Wang Ningyu3,Gao Chao4,Zhao Lifeng5,Yu Luoting1ORCID

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China

2. College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160, China

3. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China

4. Institute of Immunology and Inflammation,Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China

5. Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, China

Funder

Ministry of Science and Technology of the People's Republic of China

Chengdu University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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