Discovery of Novel, Potent, and Selective Small-Molecule Menin–Mixed Lineage Leukemia Interaction Inhibitors through Attempting Introduction of Hydrophilic Groups-Reference-Cited by-同舟云学术

Discovery of Novel, Potent, and Selective Small-Molecule Menin–Mixed Lineage Leukemia Interaction Inhibitors through Attempting Introduction of Hydrophilic Groups

Published:2022-09-29 Issue:19 Volume:65 Page:13413-13435
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lei Hao¹,Zhang San-Qi¹,Bai Huanrong¹,Zhao Hong-Yi¹^ORCID,Sun Jiajia¹,Chuai Hongyan¹,Xin Minhang¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, Xi’an Jiaotong University, Xi’an, Shaanxi710061, P. R. China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shaanxi Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01313

Reference38 articles.

1. MLL translocations, histone modifications and leukaemia stem-cell development

2. Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological Interventions

3. LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias

4. AF4 Encodes a Ubiquitous Protein That in Both Native and MLL-AF4 Fusion Types Localizes to Subnuclear Compartments

5. MLL fusion partners AF4 and AF9 interact at subnuclear foci

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