Identification of 5-(Aryl/Heteroaryl)amino-4-quinolones as Potent Membrane-Disrupting Agents to Combat Antibiotic-Resistant Gram-Positive Bacteria-Reference-Cited by-同舟云学术

Identification of 5-(Aryl/Heteroaryl)amino-4-quinolones as Potent Membrane-Disrupting Agents to Combat Antibiotic-Resistant Gram-Positive Bacteria

Published:2022-10-11 Issue:20 Volume:65 Page:13910-13934
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Schultz John R.¹,Costa Stephen K.²,Jachak Gorakhnath R.¹,Hegde Pooja¹,Zimmerman Matthew³,Pan Yan³,Josten Michaele⁴,Ejeh Chinedu²,Hammerstad Travis¹,Sahl Hans Georg⁴,Pereira Pedro M.⁵^ORCID,Pinho Mariana G.⁵,Dartois Véronique³^ORCID,Cheung Ambrose²,Aldrich Courtney C.¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States

2. Department of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755, United States

3. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States

4. Institute for Pharmaceutical Microbiology and Institute for Medical Microbiology, Immunology, and Parasitology, University of Bonn, D-53115 Bonn, Germany

5. Bacterial Cell Biology Laboratory, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Avenida da República (EAN), 2781-901 Oeiras, Portugal

Funder

National Institute of Allergy and Infectious Diseases

?la Caixa? Foundation

H2020 Marie Sklodowska-Curie Actions

H2020 European Research Council

Microbiologia Molecular, Estrutural e Celular

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01151