Modifying a Hydroxyl Patch in Glucagon-like Peptide 1 Produces Biased Agonists with Unique Signaling Profiles-Reference-Cited by-同舟云学术

Modifying a Hydroxyl Patch in Glucagon-like Peptide 1 Produces Biased Agonists with Unique Signaling Profiles

Published:2022-08-19 Issue:17 Volume:65 Page:11759-11775
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Peiqi¹²,Hill Timothy A.¹³^ORCID,Mitchell Justin¹²,Fitzsimmons Rebecca L.¹²⁴^ORCID,Xu Weijun¹²,Loh Zhixuan¹²⁴,Suen Jacky Y.¹²,Lim Junxian¹²³⁴^ORCID,Iyer Abishek¹²³⁴,Fairlie David P.¹²³⁴^ORCID

Affiliation:

1. Institute for Molecular Bioscience, The University of Queensland, Brisbane Queensland 4072, Australia

2. Australian Research Council Centre of Excellence in Advanced Molecular Imaging, The University of Queensland, Brisbane Queensland 4072, Australia

3. Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane Queensland 4072, Australia

4. Centre for Inflammation and Disease Research, The University of Queensland, Brisbane Queensland 4072, Australia

Funder

National Health and Medical Research Council

Australian Research Council

Australian Research Council Centre of Excellence in Advanced Molecular Imaging

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00653

Reference71 articles.