<i>N</i>-Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction-Reference-Cited by-同舟云学术

N-Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction

Published:2022-07-05 Issue:13 Volume:65 Page:9126-9143
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wen Wuqiang¹,Cao Hongxuan¹,Xu Yixiang²,Ren Yanliang¹^ORCID,Rao Li¹^ORCID,Shao Xubo¹,Chen Han¹,Wu Lixia¹,Liu Jiaqi¹,Su Chen³,Peng Chao³,Huang Yunyuan¹²,Wan Jian¹^ORCID

Affiliation:

1. Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China

2. Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

3. National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai 201210, China

Funder

Guizi Scholarship of CCNU

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00336

Reference78 articles.

1. Regio- and Stereospecific Synthesis of Oridonin D-Ring Aziridinated Analogues for the Treatment of Triple-Negative Breast Cancer via Mediated Irreversible Covalent Warheads