From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human α9α10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue-Reference-Cited by-同舟云学术

From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human α9α10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue

Published:2022-07-14 Issue:14 Volume:65 Page:10079-10097
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bavo Francesco¹²,Pallavicini Marco¹^ORCID,Pucci Susanna³⁴,Appiani Rebecca¹,Giraudo Alessandro¹^ORCID,Eaton Brek⁵,Lucero Linda⁵,Gotti Cecilia³,Moretti Milena³⁶,Whiteaker Paul⁷,Bolchi Cristiano¹^ORCID

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, via Mangiagalli 25, I-20133 Milano, Italy

2. Department of Drug Design and Pharmacology, University of Copenhagen, DK-2100 Copenhagen, Denmark

3. Institute of Neuroscience, CNR, via Vanvitelli 32, I-20129 Milano, Italy

4. NeuroMi Milan Center for Neuroscience, University of Milano Bicocca, piazza Ateneo Nuovo 1, I-20126 Milano, Italy

5. Division of Neurobiology, Barrow Neurological Institute, Phoenix, Arizona 85013, United States

6. Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, via Vanvitelli 32, I-20129 Milano, Italy

7. Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, United States

Funder

Università degli Studi di Milano

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00746

Reference32 articles.

1. Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors

2. α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells

3. 10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells

4. Commentary: Nicotinic Acetylcholine Receptor α9 and α10 Subunits Are Expressed in the Brain of Mice

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