Design and Characterization of a Natural Arf-GEFs Inhibitor Prodrug <b>CHNQD-01255</b> with Potent Anti-Hepatocellular Carcinoma Efficacy <i>In Vivo</i>-Reference-Cited by-同舟云学术

Design and Characterization of a Natural Arf-GEFs Inhibitor Prodrug CHNQD-01255 with Potent Anti-Hepatocellular Carcinoma Efficacy In Vivo

Published:2022-09-12 Issue:18 Volume:65 Page:11970-11984
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jiang Yao-Yao¹²,Gao Yang¹,Liu Jian-Yu¹,Xu Ying¹,Wei Mei-Yan¹,Wang Chang-Yun¹²^ORCID,Gu Yu-Cheng³^ORCID,Shao Chang-Lun¹²^ORCID

Affiliation:

1. Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China

2. Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266200, China

3. Syngenta Jealott’s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, U.K.

Funder

Taishan Scholar Project of Shandong Province

Central University Basic Research Fund of China

Polit National Laboratory for Marine Science and Technology

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00532

Reference42 articles.

1. Current Perspective of Traditional Chinese Medicines and Active Ingredients in the Therapy of Hepatocellular Carcinoma

2. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

3. Immunotherapy for hepatocellular carcinoma

4. Immunotherapies for hepatocellular carcinoma

5. Immunotherapy for Hepatocellular Carcinoma: A 2021 Update

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