Design and Characterization of a Natural Arf-GEFs Inhibitor Prodrug CHNQD-01255 with Potent Anti-Hepatocellular Carcinoma Efficacy In Vivo

Author:

Jiang Yao-Yao12,Gao Yang1,Liu Jian-Yu1,Xu Ying1,Wei Mei-Yan1,Wang Chang-Yun12ORCID,Gu Yu-Cheng3ORCID,Shao Chang-Lun12ORCID

Affiliation:

1. Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China

2. Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266200, China

3. Syngenta Jealott’s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, U.K.

Funder

Taishan Scholar Project of Shandong Province

Central University Basic Research Fund of China

Polit National Laboratory for Marine Science and Technology

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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