The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation

Author:

Flegel Jana12,Shaaban Saad13,Jia Zhi Jun14,Schulte Britta12,Lian Yilong5,Krzyzanowski Adrian12,Metz Malte1,Schneidewind Tabea12,Wesseler Fabian12,Flegel Anke1,Reich Alisa1,Brause Alexandra1,Xue Gang1,Zhang Minghao6,Dötsch Lara12ORCID,Stender Isabelle D.7,Hoffmann Jan-Erik7,Scheel Rebecca8,Janning Petra1,Rastinejad Fraydoon6,Schade Dennis9ORCID,Strohmann Carsten8,Antonchick Andrey P.1210ORCID,Sievers Sonja111,Moura-Alves Pedro51213,Ziegler Slava1ORCID,Waldmann Herbert12ORCID

Affiliation:

1. Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany

2. Faculty of Chemistry, Chemical Biology, Technical University Dortmund, Dortmund 44227, Germany

3. Faculty of Chemistry, Institute of Organic Chemistry, University of Vienna Währinger Str. 38, Vienna 1090, Austria

4. Key Laboratory of Birth Defects and Related Diseases of Women and Children, Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu 610041, China

5. Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom

6. Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, OX3 7FZ, UK

7. Protein Chemistry Facility, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany

8. Faculty of Chemistry, Inorganic Chemistry, Technical University Dortmund, Dortmund 44227, Germany

9. Dept. of Pharmaceutical & Medicinal Chemistry, Institute of Pharmacy, Christian-Albrechts-University of Kiel, Kiel 24118, Germany

10. Department of Chemistry and Forensics, School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, United Kingdom

11. Compound Management and Screening Center, Dortmund 44227, Germany

12. i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal

13. IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal

Funder

Ludwig Institute for Cancer Research

Max-Planck-Gesellschaft

Verband der Chemischen Industrie

Technische Universit?t Dortmund

H2020 Spreading Excellence and Widening Participation

Aventis Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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