Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction–Reconstruction and Fragment-Growing Approach-Reference-Cited by-同舟云学术

Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction–Reconstruction and Fragment-Growing Approach

Published:2022-04-28 Issue:17 Volume:65 Page:11574-11606
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Iannelli Giulia,Milite Ciro^ORCID,Marechal Nils¹²³⁴,Cura Vincent¹²³⁴,Bonnefond Luc¹²³⁴^ORCID,Troffer-Charlier Nathalie¹²³⁴,Feoli Alessandra^ORCID,Rescigno Donatella^ORCID,Wang Yalong⁵,Cipriano Alessandra,Viviano Monica^ORCID,Bedford Mark T.⁵,Cavarelli Jean¹²³⁴,Castellano Sabrina^ORCID,Sbardella Gianluca^ORCID

Affiliation:

1. Department of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67400 Illkirch, France

2. Centre National de la Recherche Scientifique, UMR7104 Illkirch, France

3. Institut National de la Santé et de la Recherche Médicale, U1258 Illkirch, France

4. Université de Strasbourg, 67400 Illkirch, France

5. Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States

Funder

Association pour la Recherche sur le Cancer

Agence Nationale de la Recherche

Institut National de la Sant? et de la Recherche M?dicale

Universit? de Strasbourg

Ministero dell?Istruzione, dell?Universit? e della Ricerca