New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate <i>Staphylococcus aureus</i>-Reference-Cited by-同舟云学术

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Published:2023-03-06 Issue:6 Volume:66 Page:3968-3994
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Durcik Martina¹^ORCID,Cotman Andrej Emanuel¹^ORCID,Toplak Žan¹,Možina Štefan¹^ORCID,Skok Žiga¹,Szili Petra Eva²,Czikkely Márton²,Maharramov Elvin²,Vu Thu Hien²,Piras Maria Vittoria¹^ORCID,Zidar Nace¹^ORCID,Ilaš Janez¹^ORCID,Zega Anamarija¹^ORCID,Trontelj Jurij¹,Pardo Luis A.³^ORCID,Hughes Diarmaid⁴,Huseby Douglas⁴^ORCID,Berruga-Fernández Tália⁴^ORCID,Cao Sha⁴,Simoff Ivailo⁵^ORCID,Svensson Richard⁵,Korol Sergiy V.⁶^ORCID,Jin Zhe⁶,Vicente Francisca⁷,Ramos Maria C.⁷^ORCID,Mundy Julia E. A.⁸,Maxwell Anthony⁸^ORCID,Stevenson Clare E. M.⁸,Lawson David M.⁸,Glinghammar Björn⁹,Sjöström Eva¹⁰,Bohlin Martin¹⁰,Oreskär Joanna¹⁰,Alvér Sofie¹⁰,Janssen Guido V.¹¹,Sterk Geert Jan¹¹,Kikelj Danijel¹,Pal Csaba²,Tomašič Tihomir¹^ORCID,Peterlin Mašič Lucija¹^ORCID

Affiliation:

1. Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, Ljubljana 1000, Slovenia

2. Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Szeged H-6726, Hungary

3. Max Planck Institute for Multidisciplinary Sciences, Oncophysiology, Hermann-Rein-Str. 3, Göttingen 37075, Germany

4. Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, Uppsala 75123, Sweden

5. Drug Optimization and Pharmaceutical Profiling Platform (UDOPP) Department of Pharmacy, Uppsala University, Husargatan 3, Uppsala 75123, Sweden

6. Department of Medical Cell Biology, Uppsala University, Husargatan 3, Uppsala 75123, Sweden

7. Fundación Medina, Avenida del Conocimiento 34, Parque Tecnológico Ciencias de la Salud, Granada 18016, Spain

8. Department of Biochemistry and Metabolism, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K.

9. Department of Chemical and Pharmaceutical Toxicology, RISE Research Institutes of Sweden, Södertälje 15136, Sweden

10. Department of Chemical Processes and Pharmaceutical Development, RISE Research Institutes of Sweden, Södertälje 15136, Sweden

11. Medicinal Chemistry Division, Vrije Universiteit Amsterdam, De Boelelaan 1108, Amsterdam 1081 HZ, The Netherlands

Funder

The Wellcome Trust DBT India Alliance

Javna Agencija za Raziskovalno Dejavnost RS

National Academy of Sciences

Innovative Medicines Initiative

H2020 European Institute of Innovation and Technology

Nemzeti Kutatási Fejlesztési és Innovációs Hivatal

European Federation of Pharmaceutical Industries and Associations

Biotechnology and Biological Sciences Research Council

Seventh Framework Programme

National Laboratory of Biotechnology

ELKH Lendület Programme

Redx Pharma Plc

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01905

Reference55 articles.

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4. O’Neill, J. Review on Antimicrobial Resistance Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations. London: Review on Antimicrobial Resistance. 2014, https://amr-review.org/sites/default/files/AMR%20Review%20Paper%20-%20Tackling%20a%20crisis%20for%20the%20health%20and%20wealth%20of%20nations_1.pdf (accessed May 13, 2022).

5. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

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