Targeting Enhancer of Zeste Homolog 2 for the Treatment of Hematological Malignancies and Solid Tumors: Candidate Structure–Activity Relationships Insights and Evolution Prospects-Reference-Cited by-同舟云学术

Targeting Enhancer of Zeste Homolog 2 for the Treatment of Hematological Malignancies and Solid Tumors: Candidate Structure–Activity Relationships Insights and Evolution Prospects

Published:2022-05-07 Issue:10 Volume:65 Page:7016-7043
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Xia Juan¹,Li Jingyi²,Tian Lei²³,Ren Xiaodong⁴,Liu Chang⁵,Liang Chengyuan²^ORCID

Affiliation:

1. Laboratory of Hematologic Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, P. R. China

2. Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi’an 710021, P. R. China

3. College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & Technology, Xi’an 710021, P. R. China

4. Medical College, Guizhou University, Guiyang 550025, P. R. China

5. Zhuhai Jinan Selenium Source Nanotechnology Co., Ltd., Zhuhai 519030, P. R. China

Funder

China Postdoctoral Science Foundation

Education Department of Shaanxi Province

National Natural Science Foundation of China

Natural Science Foundation of Shaanxi Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00047

Reference173 articles.

1. Strategy for “Detoxification” of a Cancer-Derived Histone Mutant Based on Mapping Its Interaction with the Methyltransferase PRC2

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4. The Murine Polycomb Group Protein Eed Is Required for Global Histone H3 Lysine-27 Methylation

5. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

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