Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond-Reference-Cited by-同舟云学术

Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond

Published:2022-06-28 Issue:13 Volume:65 Page:9159-9173
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yang Jianhong¹,Li Yong¹,Qiu Qiang¹,Wang Ruihan²,Yan Wei¹,Yu Yamei¹,Niu Lu¹,Pei Heying¹,Wei Haoche¹,Ouyang Liang¹^ORCID,Ye Haoyu¹^ORCID,Xu Dingguo²^ORCID,Wei Yuquan¹,Chen Qiang¹,Chen Lijuan¹^ORCID

Affiliation:

1. Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China

2. MOE Key Laboratory of Green Chemistry and Technology, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China

Funder

China Postdoctoral Science Foundation

National Natural Science Foundation of China

1.3.5 Project for Disciplines of excellence, West China Hospital, Sichuan University

PostDoctor Research Project, Sichuan University

Sichuan Science and Technology Program

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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