Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists-Reference-Cited by-同舟云学术

Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists

Published:2022-10-06 Issue:20 Volume:65 Page:14082-14103
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Vavřina Zdeněk¹²^ORCID,Perlíková Pavla¹³^ORCID,Milisavljević Nemanja¹⁴,Chevrier Florian¹,Smola Miroslav¹,Smith Joshua¹⁵,Dejmek Milan¹^ORCID,Havlíček Vojtěch¹⁴,Buděšínský Miloš¹,Liboska Radek¹,Vaneková Lenka¹⁶^ORCID,Brynda Jiří¹,Boura Evzen¹^ORCID,Řezáčová Pavlína¹,Hocek Michal¹^ORCID,Birkuš Gabriel¹^ORCID

Affiliation:

1. Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo Namesti 542, Prague 166 10, Czech Republic

2. Department of Biochemistry, Faculty of Science, Charles University, Hlavova 2030/8, Prague 128 00, Czech Republic

3. Department of Organic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology, Technicka 5, Prague 166 28, Czech Republic

4. Department of Organic Chemistry, Faculty of Science, Charles University, Hlavova 2030/8, Prague 128 00, Czech Republic

5. First Faculty of Medicine, Charles University, Katerinska 1660/32, Prague 121 08, Czech Republic

6. Department of Cell Biology, Faculty of Science, Charles University, Vinicna 1594/7, Prague 128 43, Czech Republic

Funder

European Regional Development Fund

Ministerstvo ?kolstv?, Ml?de?e a Telov?chovy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01305

Reference61 articles.

1. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

2. The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

3. Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

4. Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

5. Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

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