Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity
Author:
Affiliation:
1. Medicines Discovery Institute, School of Biosciences, Cardiff University, Cardiff CF10 3AT, United Kingdom
2. Centre for Medicines Discovery, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, United Kingdom
Funder
Medical Research Council
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00751
Reference37 articles.
1. LIM kinases: function, regulation and association with human disease
2. LIM kinases are attractive targets with many macromolecular partners and only a few small molecule regulators
3. LIM kinases: cofilin and beyond
4. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
5. Control of Actin Reorganization by Slingshot, a Family of Phosphatases that Dephosphorylate ADF/Cofilin
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