Novel Benzo Five-Membered Heterocycle Derivatives as P-Glycoprotein Inhibitors: Design, Synthesis, Molecular Docking, and Anti-Multidrug Resistance Activity-Reference-Cited by-同舟云学术

Novel Benzo Five-Membered Heterocycle Derivatives as P-Glycoprotein Inhibitors: Design, Synthesis, Molecular Docking, and Anti-Multidrug Resistance Activity

Published:2023-04-03 Issue:8 Volume:66 Page:5550-5566
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yang Zhikun¹^ORCID,Cai Yue¹,Yang Xue²,Li Yasheng³,Wu Qihao⁴⁵,Yu Yanlei¹,Chen Zhen¹,Wei Bin¹^ORCID,Tian Jin-Miao¹,Bao Xiaoze¹^ORCID,Ye Xinyi¹^ORCID,Chen Jianwei¹^ORCID,Zhang Huawei¹^ORCID,Mou Xiaozhou²,Sun Xuanrong¹^ORCID,Wang Hong¹^ORCID

Affiliation:

1. College of Pharmaceutical Science & Green Pharmaceutical Collaborative Innovation Center of Yangtze River Delta Region, Zhejiang University of Technology, Hangzhou 310014, China

2. General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou 310014, China

3. Department of Infectious Diseases & Anhui Center for Surveillance of Bacterial Resistance, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

4. Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States

5. Institute of Biomolecular Design & Discovery, Yale University, West Haven, Connecticut 06516, United States

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

High-Level Talent Special Support Plan of Zhejiang Province

Key Research and Development Program of Zhejiang Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine