Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer-Reference-Cited by-同舟云学术

Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer

Published:2022-07-15 Issue:14 Volume:65 Page:9662-9677
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Eno Meredith S.¹^ORCID,Brubaker Jason D.¹,Campbell John E.¹,De Savi Chris¹,Guzi Timothy J.¹,Williams Brett D.¹,Wilson Douglas¹,Wilson Kevin¹^ORCID,Brooijmans Natasja¹,Kim Joseph¹,Özen Ayşegül¹,Perola Emanuele¹,Hsieh John¹,Brown Victoria¹,Fetalvero Kristina¹,Garner Andrew¹,Zhang Zhuo¹,Stevison Faith¹,Woessner Rich¹,Singh Jatinder¹,Timsit Yoav¹,Kinkema Caitlin¹,Medendorp Clare¹,Lee Christopher¹,Albayya Faris¹,Zalutskaya Alena¹,Schalm Stefanie¹,Dineen Thomas A.¹

Affiliation:

1. Blueprint Medicines, 45 Sidney Street, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00704

Reference62 articles.

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3. Overview of current systemic management of EGFR-mutant NSCLC

4. Non-small-cell lung cancer harbouring mutations in the EGFR kinase domain

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