Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-<i>a</i>]pyrimidine-Based Macrocycles-Reference-Cited by-同舟云学术

Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-a]pyrimidine-Based Macrocycles

Published:2022-05-24 Issue:11 Volume:65 Page:7799-7817
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kurz Christian G.¹²,Preuss Franziska¹²,Tjaden Amelie¹²,Cusack Martin³,Amrhein Jennifer Alisa¹²,Chatterjee Deep¹²,Mathea Sebastian¹²^ORCID,Berger Lena Marie¹²^ORCID,Berger Benedict-Tilman¹²^ORCID,Krämer Andreas¹²⁴,Weller Michael³,Weiss Tobias³,Müller Susanne¹²^ORCID,Knapp Stefan¹²^ORCID,Hanke Thomas¹²^ORCID

Affiliation:

1. Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Straße 9, Frankfurt 60438, Germany

2. Structural Genomics Consortium, Buchman Institute for Molecular Life Science (BMLS), Max-von-Laue-Straße 15, Frankfurt 60438, Germany

3. Department of Neurology and Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Frauenklinikstrasse 26, Zurich 8091, Switzerland

4. Frankfurt Cancer Institute (FCI), Paul-Ehrlich-Straße 42-44, Frankfurt 60596, Germany

Funder

Deutsche Forschungsgemeinschaft

Structural Genomics Consortium

Innovative Medicines Initiative 2 Joint Undertaking (JU)

FUGG

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00173