Mechanism of Action and Structure–Activity Relationship of α-Conotoxin Mr1.1 at the Human α9α10 Nicotinic Acetylcholine Receptor-Reference-Cited by-同舟云学术

Mechanism of Action and Structure–Activity Relationship of α-Conotoxin Mr1.1 at the Human α9α10 Nicotinic Acetylcholine Receptor

Published:2022-09-22 Issue:24 Volume:65 Page:16204-16217
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liang Jiazhen¹²,Tae Han-Shen³^ORCID,Zhao Zitong¹²,Li Xiao¹²,Zhang Jinghui¹²,Chen Shen¹²,Jiang Tao¹²⁴^ORCID,Adams David J.³^ORCID,Yu Rilei¹²⁴^ORCID

Affiliation:

1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao266003, China

2. Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao266003, China

3. Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, Wollongong, New South Wales2522, Australia

4. Innovation Center for Marine Drug Screening & Evaluation, Qingdao National Laboratory for Marine Science and Technology, Qingdao266003, China

Funder

Central University Basic Research Fund of China

Australian Research Council

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00494

Reference46 articles.

1. Nicotinic acetylcholine receptors: From basic science to therapeutics

2. Nicotinic acetylcholine receptors: Conventional and unconventional ligands and signaling

3. Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

4. Molecular mechanism for analgesia involving specific antagonism of 9 10 nicotinic acetylcholine receptors

5. Interacting with 7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages

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