Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum α-Glucosidase I with Anti-SARS-CoV-2 Activity

Author:

Karade Sharanbasappa S.12ORCID,Franco Evelyn J.3,Rojas Ana C.3,Hanrahan Kaley C.3,Kolesnikov Alexander12,Yu Wenbo145,MacKerell Alexander D.145,Hill Daniel C.6,Weber David J.15,Brown Ashley N.3ORCID,Treston Anthony M.6ORCID,Mariuzza Roy A.12ORCID

Affiliation:

1. University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, Maryland 20850, United States

2. Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, United States

3. Institute for Therapeutic Innovation, Department of Medicine, College of Medicine, University of Florida, Orlando, Florida 32827, United States

4. Computer-Aided Drug Design Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, United States

5. Center for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, Maryland 21201, United States

6. Emergent BioSolutions, Gaithersburg, Maryland 20879, United States

Funder

University of Maryland

Emergent BioSolutions

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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