Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2-<i>b</i>]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2-b]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors

Published:2022-10-24 Issue:21 Volume:65 Page:14809-14831
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yang Fang¹,Chen Xiaojuan²,Song Xiaojuan¹,Ortega Raquel³,Lin Xiaojing³,Deng Wuqing¹,Guo Jing¹,Tu Zhengchao¹,Patterson Adam V.³⁴,Smaill Jeff B.³⁴,Chen Yongheng²^ORCID,Lu Xiaoyun¹^ORCID

Affiliation:

1. International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, #855 Xingye Avenue, Guangzhou 510632, China

2. Department of Oncology, NHC Key Laboratory of Cancer Proteomics, State Local Joint Engineering Laboratory for Anticancer Drugs, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China

3. Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

4. Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

Funder

Ministry of Science and Technology of the People's Republic of China

Health Research Council of New Zealand

Jinan University

National Natural Science Foundation of China

Guangdong Province Science and Technology Program

Cancer Society Auckland Northland

China Maurice Wilkins Centre Collaborative Research Program

Publisher

American Chemical Society (ACS)

Subject