Discovery of AXL Degraders with Improved Potencies in Triple-Negative Breast Cancer (TNBC) Cells

Author:

He Rui1,Song Zhiqiang2,Bai Yu2,He Sheng1,Huang Jing1,Wang Yongxing3,Zhou Fengtao1ORCID,Huang Weixue2,Guo Jing1,Wang Zhen2ORCID,Tu Zheng-Chao1,Ren Xiaomei2,Zhang Zhang1ORCID,Xu Jian3,Ding Ke124ORCID

Affiliation:

1. International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy, Jinan University, 855 Xingye Avenue, Panyu District, Guangzhou 510632, China

2. State Key Laboratory of Bioorganic & Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

3. Livzon Research Institute, Livzon Pharmaceutical Group Inc., 38 Chuangye North Road, Jinwan District, Zhuhai 519000, China

4. The First Affiliated Hospital (Huaqiao Hospital), Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China

Funder

Ministry of Science and Technology of the People's Republic of China

Shenzhen Bay Laboratory

National Natural Science Foundation of China

State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

Livzon Pharmaceutical Group Inc.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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