Self-Adjuvanting Protein Vaccine Conjugated with a Novel Synthetic TLR4 Agonist on Virus-Like Liposome Induces Potent Immunity against SARS-CoV-2

Author:

Ding Dong1,Wen Yu1,Liao Chun-Miao1,Yin Xu-Guang2,Zhang Ru-Yan1,Wang Jian1,Zhou Shi-Hao1,Zhang Zhi-Ming1,Zou Yong-Ke1,Gao Xiao-Fei3,Wei Hua-Wei4,Yang Guang-Fu1ORCID,Guo Jun1ORCID

Affiliation:

1. Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, College of Chemistry, Central China Normal University, Wuhan 430079, China

2. School of Medicine, Shaoxing University, Shaoxing 312000, China

3. Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang 330013, China

4. Jiangsu East-Mab Biomedical Technology Co. Ltd, Nantong 226499, China

Funder

Ministry of Science and Technology of the People's Republic of China

Central University Basic Research Fund of China

Wuhan Municipal Science and Technology Bureau

National Natural Science Foundation of China

Higher Education Discipline Innovation Project

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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