Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring <i>MET</i> Gene Alteration Treatment-Reference-Cited by-同舟云学术

Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment

Published:2022-11-10 Issue:22 Volume:65 Page:15140-15164
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Chaofan¹,Li Jie¹,Qu Lingzhi²,Tang Xia¹,Song Xiaojuan¹,Yang Fang¹,Chen Xiaojuan²,Lin Qianmeng²,Lin Weibin¹,Zhou Yang¹^ORCID,Tu ZhengChao¹,Chen Yongheng²^ORCID,Zhang Zhang¹^ORCID,Lu Xiaoyun¹^ORCID

Affiliation:

1. International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, #855 Xingye Avenue, Guangzhou 510632, China

2. Department of Oncology, NHC Key Laboratory of Cancer Proteomics, State Local Joint Engineering Laboratory for Anticancer Drugs, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China

Funder

Ministry of Science and Technology of the People's Republic of China

Jinan University

National Natural Science Foundation of China

State Key Laboratory of Esophageal Cancer Prevention and Treatment

Wang Kuancheng Young Scholar

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00981