Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19-Reference-Cited by-同舟云学术

Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19

Published:2022-03-30 Issue:9 Volume:65 Page:6499-6512
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Unoh Yuto¹,Uehara Shota¹^ORCID,Nakahara Kenji¹,Nobori Haruaki¹,Yamatsu Yukiko¹,Yamamoto Shiho¹^ORCID,Maruyama Yuki¹²,Taoda Yoshiyuki¹^ORCID,Kasamatsu Koji¹,Suto Takahiro¹,Kouki Kensuke¹,Nakahashi Atsufumi¹,Kawashima Sho¹,Sanaki Takao¹,Toba Shinsuke¹²,Uemura Kentaro¹²,Mizutare Tohru¹,Ando Shigeru¹^ORCID,Sasaki Michihito²,Orba Yasuko²,Sawa Hirofumi²,Sato Akihiko¹²,Sato Takafumi¹,Kato Teruhisa¹,Tachibana Yuki¹^ORCID

Affiliation:

1. Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan

2. International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan

Funder

Shionogi

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00117

Reference40 articles.

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2. WHO. Target Product Profiles for COVID-19 Therapeutics for non-hospitalized patients. https://www.who.int/publications/m/item/who-target-product-profiles-for-covid-19-therapeutics-for-non-hospitalized-patients (accessed 2022-01-12).

3. Characteristics of SARS-CoV-2 and COVID-19

4. The SARS-CoV-2 main protease as drug target

5. Proteases and protease inhibitors in infectious diseases

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