Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19
Author:
Affiliation:
1. Shionogi Pharmaceutical Research Center, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan
2. International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan
Funder
Shionogi
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00117
Reference40 articles.
1. WHO. Coronavirus (COVID-19) Dashboard. https://covid19.who.int (accessed 2022-03-07).
2. WHO. Target Product Profiles for COVID-19 Therapeutics for non-hospitalized patients. https://www.who.int/publications/m/item/who-target-product-profiles-for-covid-19-therapeutics-for-non-hospitalized-patients (accessed 2022-01-12).
3. Characteristics of SARS-CoV-2 and COVID-19
4. The SARS-CoV-2 main protease as drug target
5. Proteases and protease inhibitors in infectious diseases
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