Fragment Libraries Designed to Be Functionally Diverse Recover Protein Binding Information More Efficiently Than Standard Structurally Diverse Libraries-Reference-Cited by-同舟云学术

Fragment Libraries Designed to Be Functionally Diverse Recover Protein Binding Information More Efficiently Than Standard Structurally Diverse Libraries

Published:2022-08-12 Issue:16 Volume:65 Page:11404-11413
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Carbery Anna¹²^ORCID,Skyner Rachael²,von Delft Frank²³^ORCID,Deane Charlotte M.¹^ORCID

Affiliation:

1. Oxford Protein Informatics Group, Department of Statistics, University of Oxford, Oxford OX1 3LB, U.K.

2. Diamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, U.K.

3. Centre for Medicines Discovery, University of Oxford, Oxford OX3 7DQ, U.K.

Funder

Engineering and Physical Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01004

Reference41 articles.

1. Twenty years on: the impact of fragments on drug discovery

2. Fragment Hits: What do They Look Like and How do They Bind?

3. C–H functionalisation tolerant to polar groups could transform fragment-based drug discovery (FBDD)

4. Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug Discovery

5. A ‘Rule of Three’ for fragment-based lead discovery?

Cited by 23 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Rescaling NMR for a Larger Deployment in Drug Discovery: Hyperpolarization and Benchtop NMR as Potential Game‐Changers;Chemistry–Methods;2024-09-05

2. Crystallographic fragment-binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate-channeling path between them;Acta Crystallographica Section D Structural Biology;2024-07-16

3. Rapid Discovery of Antimicrobial and Antimalarial Agents from Natural Product Fragments;Separations;2024-06-23

4. Building Block-Centric Approach to DNA-Encoded Library Design;Journal of Chemical Information and Modeling;2024-06-11

5. Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction;2024-06-03