Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates-Reference-Cited by-同舟云学术

Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates

Published:2022-11-08 Issue:22 Volume:65 Page:15208-15226
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Miller Michael¹,Rossetti Thomas²,Ferreira Jacob²,Ghanem Lubna²,Balbach Melanie²,Kaur Navpreet²,Levin Lonny R.²^ORCID,Buck Jochen²,Kehr Maria³,Coquille Sandrine³^ORCID,van den Heuvel Joop⁴,Steegborn Clemens³^ORCID,Fushimi Makoto¹,Finkin-Groner Efrat¹,Myers Robert W.¹^ORCID,Kargman Stacia¹,Liverton Nigel J.¹,Huggins David J.¹⁵^ORCID,Meinke Peter T.¹²

Affiliation:

1. Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States

2. Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States

3. Department of Biochemistry, University of Bayreuth, 95440 Bayreuth, Germany

4. Helmholtz Centre for Infection Research, Recombinant Protein Expression, Inhoffenstrasse 7, 38124 Braunschweig, Germany

5. Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York 10021, United States

Funder

Foundation for the National Institutes of Health

Male Contraceptive Initiative

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01133

Reference54 articles.

1. Physiological roles of mammalian transmembrane adenylyl cyclase isoforms

2. Pharmacological modulation of the CO2/HCO3−/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase

3. Molecular Details of cAMP Generation in Mammalian Cells: A Tale of Two Systems

4. Soluble adenylyl cyclase is essential for proper lysosomal acidification

5. Role of soluble adenylyl cyclase in mitochondria

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