Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis <i>In Vivo</i>-Reference-Cited by-同舟云学术

Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo

Published:2023-03-06 Issue:6 Volume:66 Page:3852-3865
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Randolph John T.¹^ORCID,O’Connor Matthew J.¹^ORCID,Han Fei¹,Hutchins Charles W.¹,Siu Y. Amy¹,Cho Min²,Zheng Yunan¹,Hickson Jonathan A.¹,Markley Jana L.¹^ORCID,Manaves Vlasios¹,Algire Mikkel¹,Baker Kenton A.¹,Chapman Alex M.¹,Gopalakrishnan Sujatha M.¹,Panchal Sanjay C.¹,Foster-Duke Kelly¹,Stolarik DeAnne F.¹,Kempf-Grote Anita¹,Dammeier Darby¹,Fossey Stacey¹,Sun Qi¹,Sun Chaohong¹,Shen Yu¹,Dart Michael J.¹,Kati Warren M.¹,Lai Albert¹,Firestone Ari J.²^ORCID,Kort Michael E.¹

Affiliation:

1. Abbvie Inc., North Chicago, Illinois 60064, United States

2. Calico Life Sciences LLC, South San Francisco, California 94080, United States

Funder

AbbVie

Calico

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01415