Blocking Non-enzymatic Functions by PROTAC-Mediated Targeted Protein Degradation-Reference-Cited by-同舟云学术

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Blocking Non-enzymatic Functions by PROTAC-Mediated Targeted Protein Degradation

Published:2022-10-28 Issue:21 Volume:65 Page:14276-14288
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sun Donghuan¹,Zhang Jing²,Dong Guoqiang¹,He Shipeng³,Sheng Chunquan¹^ORCID

Affiliation:

1. School of Pharmacy, Second Military Medical University (Naval Medical University), Shanghai 200433, China

2. Department of Pathology, Changzheng Hospital, Second Military Medical University (Naval Medical University), Shanghai 200003, China

3. Institute of Translational Medicine, Shanghai University, Shanghai 200444, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01159

Reference93 articles.

1. FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice

2. There’s more to death than life: Noncatalytic functions in kinase and pseudokinase signaling

3. Targeting the MDM2–p53 Protein–Protein Interaction for New Cancer Therapy: Progress and Challenges

4. Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer

5. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression

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1. Design, synthesis, anti-tumor activity and mechanism of novel PROTACs as degraders of PD-L1 and inhibitors of PD-1/PD-L1 interaction;Bioorganic & Medicinal Chemistry;2024-09

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3. HDAC6 mediates tumorigenesis during mitosis and the development of targeted deactivating agents;Bioorganic Chemistry;2024-09

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5. A one-pot photocatalytic triazole-based linkerology for PROTACs;Cell Reports Physical Science;2024-08

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