Discovery of 2-Aminopyrimidines as Potent Agonists for the Bitter Taste Receptor TAS2R14-Reference-Cited by-同舟云学术

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Discovery of 2-Aminopyrimidines as Potent Agonists for the Bitter Taste Receptor TAS2R14

Published:2023-02-27 Issue:5 Volume:66 Page:3499-3521
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Waterloo Lukas¹,Hübner Harald¹,Fierro Fabrizio²,Pfeiffer Tara¹^ORCID,Brox Regine¹,Löber Stefan¹,Weikert Dorothee¹^ORCID,Niv Masha Y.²,Gmeiner Peter¹^ORCID

Affiliation:

1. Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, Erlangen 91058, Germany

2. The Robert H. Smith Faculty of Agriculture, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University, Rehovot 7610001, Israel

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01997

Reference53 articles.

1. GPCRdb: the G protein‐coupled receptor database – an introduction

2. The receptors and cells for mammalian taste

3. Analysis of the expression of human bitter taste receptors in extraoral tissues

4. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction

5. Bitter Taste Receptors for Asthma Therapeutics

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1. Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future;Medicinal Research Reviews;2024-08-22

2. Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist;Cell Research;2024-07-05

3. Bitter taste TAS2R14 activation by intracellular tastants and cholesterol;Nature;2024-05-22

4. BitterMasS: Predicting Bitterness from Mass Spectra;Journal of Agricultural and Food Chemistry;2024-04-30

5. Unlocking TAS2R14 activation through intricate multi-ligand binding networks;2024-04-15

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