Butyrylation Meets Adipogenesis-Probed by a p300-Catalyzed Acylation-Specific Small Molecule Inhibitor: Implication in Anti-obesity Therapy-Reference-Cited by-同舟云学术

Butyrylation Meets Adipogenesis-Probed by a p300-Catalyzed Acylation-Specific Small Molecule Inhibitor: Implication in Anti-obesity Therapy

Published:2022-09-08 Issue:18 Volume:65 Page:12273-12291
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bhattacharya Aditya¹,Chatterjee Sourav¹,Bhaduri Utsa²,Singh Akash Kumar¹,Vasudevan Madavan³,Sashidhara Koneni V.⁴,Guha Rajdeep⁵,Nazir Aamir⁶,Rath Srikanta Kumar⁶,Natesh Nagashayana⁷,Kundu Tapas K.¹⁸^ORCID

Affiliation:

1. Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India

2. Chromatin Biology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India

3. Theomics International Pvt Ltd, Bangalore 560038, India

4. Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India

5. Division of Laboratory Animal Facility, CSIR-Central Drug Research Institute, Lucknow 226031, India

6. Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow 226031, India

7. Central Government Health Scheme Wellness Centre Number 8, Domlur, Bangalore 560071, India

8. Division of Neuroscience and Aging Biology, CSIR-Central Drug Research Institute, Lucknow 226031, India

Funder

University Grants Commission

Department of Science and Technology, Ministry of Science and Technology, India

Jawaharlal Nehru Centre for Advanced Scientific Research

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00943

Reference42 articles.

1. Metabolism and the Epigenome: A Dynamic Relationship

2. Lysine Propionylation and Butyrylation Are Novel Post-translational Modifications in Histones

3. Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters

4. Down-regulation of Histone Deacetylases Stimulates Adipocyte Differentiation

5. ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

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