Discovery of (<i>E</i>)-3-(3-((2-Cyano-4′-dimethylaminobiphenyl-4-ylmethyl)cyclohexanecarbonylamino)-5-fluorophenyl)acrylic Acid Methyl Ester, an Intestine-Specific, FXR Partial Agonist for the Treatment of Nonalcoholic Steatohepatitis-Reference-Cited by-同舟云学术

Discovery of (E)-3-(3-((2-Cyano-4′-dimethylaminobiphenyl-4-ylmethyl)cyclohexanecarbonylamino)-5-fluorophenyl)acrylic Acid Methyl Ester, an Intestine-Specific, FXR Partial Agonist for the Treatment of Nonalcoholic Steatohepatitis

Published:2022-07-07 Issue:14 Volume:65 Page:9974-10000
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shim Soyeon¹²,Krishnaiah Maddeboina¹,Sankham Madhusudana Reddy¹,Kim Inha¹,Lee Yoseob³,Shin Irin¹,Oh A Reum¹,Lee Hwa Jeong¹,Vu Thi Ngoc Lan¹,Park Jongmi¹,Choi Sun¹^ORCID,Park Seojeong¹,Kwon Youngjoo¹^ORCID,Fang Sungsoon⁴,Kim Dae-Kee¹²^ORCID

Affiliation:

1. College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea

2. EWHA DrugDesignHouse, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea

3. Graduate school of Medical Science, Brain Korea 21 Project, Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul 03722, Korea

4. Graduate school of Medical Science, Brain Korea 21 Project, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul 03722, Korea

Funder

Ministry of Health and Welfare

Ministry of Science and ICT, South Korea

National Research Foundation of Korea

Ewha Womans University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00641

Reference50 articles.