Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity-Reference-Cited by-同舟云学术

Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity

Published:2022-05-02 Issue:9 Volume:65 Page:6903-6925
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Govender Preshendren¹^ORCID,Müller Rudolf¹,Singh Kawaljit¹,Reddy Virsinha¹,Eyermann Charles J.¹,Fienberg Stephen¹,Ghorpade Sandeep R.¹^ORCID,Koekemoer Lizbé²,Myrick Alissa²,Schnappinger Dirk³,Engelhart Curtis³,Meshanni Jaclynn³,Byl Jo Ann W.⁴,Osheroff Neil⁴⁵⁶^ORCID,Singh Vinayak¹²^ORCID,Chibale Kelly¹²^ORCID,Basarab Gregory S.¹⁷^ORCID

Affiliation:

1. Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa

2. Drug Discovery and Development Centre (H3D) South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, Cape Town 7701, South Africa

3. Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, United States

4. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

5. Department of Medicine (Hematology/Oncology), Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

6. VA Tennessee Valley Healthcare System, Nashville, Tennessee 37212, United States

7. Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, Cape Town, 7935, South Africa

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

University of Cape Town

National Institute of General Medical Sciences

Department of Science and Innovation, South Africa

South African Medical Research Council

Biomedical Laboratory Research and Development, U.S. Department of Veterans Affairs

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00266

Reference53 articles.

1. Tuberculosis: Key facts. https://www.who.int/news-room/fact-sheets/detail/tuberculosis (accessed February 14, 2022).

2. New TB drugs. https://tbfacts.org/new-tb-drugs/ (accessed February 14, 2022).

3. Two Decades of TB Drug Discovery Efforts—What Have We Learned?

4. Strategies to Combat Multi-Drug Resistance in Tuberculosis

5. Mechanism of Quinolone Action and Resistance

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