Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase-Reference-Cited by-同舟云学术

Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase

Published:2022-10-31 Issue:21 Volume:65 Page:14326-14336
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tichenor Mark S.¹^ORCID,Wiener John J. M.¹,Rao Navin L.²,Bacani Genesis M.¹,Wei Jianmei¹,Pooley Deckhut Charlotte¹,Barbay J. Kent²,Kreutter Kevin D.²,Chang Leon¹,Clancy Kathleen W.²,Murrey Heather E.²,Wang Weixue²,Ahn Kay²^ORCID,Huber Michael¹,Rex Elizabeth¹,Coe Kevin J.¹,Wu Jiejun¹,Rui Haopeng³,Sepassi Kia¹,Gaudiano Marcello⁴,Bekkers Mariette⁴,Cornelissen Ivo⁴,Packman Kathryn⁴,Seierstad Mark¹^ORCID,Xiouras Christos⁴^ORCID,Bembenek Scott D.¹,Alexander Richard²,Milligan Cynthia²,Balasubramanian Sriram²^ORCID,Lebsack Alec D.¹,Venable Jennifer D.¹,Philippar Ulrike⁴,Edwards James P.¹,Hirst Gavin¹

Affiliation:

1. Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States

2. Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States

3. Janssen Research & Development, 4560 Jinke Road, Pudong New Area, Shanghai 201319, P. R. China

4. Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium

Funder

Janssen Research and Development

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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