Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro-<i>4H</i>-[1,2,3]triazolo[4,5-<i>c</i>]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor-Reference-Cited by-同舟云学术

Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor

Published:2022-05-18 Issue:11 Volume:65 Page:7833-7842
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ouyang Yifan¹,Si Hongfei¹,Zhu Chengjun¹,Zhong Liang¹,Ma Haowen¹,Li Zongyang²,Xiong Huilan¹,Liu Tongzheng¹,Liu Zhong³^ORCID,Zhang Zhang¹,Zhang Zhi-Min¹,Cai Qian¹^ORCID

Affiliation:

1. College of Pharmacy, Jinan University, No. 601 Huangpu Avenue West, Guangzhou 510530, China

2. Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen 518035, China

3. Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan University, No. 601 Huangpu Avenue West, Guangzhou 510632, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Science and Technology Planning Project of Guangzhou City

"The Pearl River Talent Recruitment Program? of Guangdong Province

Guangdong Key Research and Development Project

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link