Discovery of Novel Sesquiterpene Lactone Derivatives as Potent PKM2 Activators for the Treatment of Ulcerative Colitis-Reference-Cited by-同舟云学术

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Discovery of Novel Sesquiterpene Lactone Derivatives as Potent PKM2 Activators for the Treatment of Ulcerative Colitis

Published:2023-04-05 Issue:8 Volume:66 Page:5500-5523
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Ping¹,Yang Hongqiong¹,Lin Weijiang¹,Zhou Jingxian¹,Liu Yi¹,Ma Lingyu¹,Li Mengting¹,Hu Yang¹,Yu Chengli¹,Zhang Yinan¹^ORCID,Lv Qi¹,Liu Jian¹^ORCID,Hu Lihong¹

Affiliation:

1. Jiangsu Key Laboratory for Functional Substances of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China

Funder

Nanjing University of Chinese Medicine

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Postgraduate Research and Practice Innovation Program of Jiangsu Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01856

Reference40 articles.

1. Inflammatory bowel disease: cause and immunobiology

2. AGA Clinical Practice Update on Diagnosis and Management of Immune Checkpoint Inhibitor Colitis and Hepatitis: Expert Review

3. Microscopic colitis: Etiopathology, diagnosis, and rational management

4. RIP3 promotes colitis-associated colorectal cancer by controlling tumor cell proliferation and CXCL1-induced immune suppression

5. Immunotherapy-induced Colitis

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1. Design, synthesis, and biological evaluation of oridonin derivatives as novel NLRP3 inflammasome inhibitors for the treatment of acute lung injury;European Journal of Medicinal Chemistry;2024-11

2. Aucklandiae radix targeted PKM2 to alleviate ulcerative colitis: Insights from the photocrosslinking target fishing technique;Phytomedicine;2024-11

3. Design, synthesis, and biological evaluation of novel sesquiterpene lactone derivatives as PKM2 activators with potent anti-ulcerative colitis activities;European Journal of Medicinal Chemistry;2024-06

4. Climbing the Oxidase Phase Ladder by Using Dioxygen as the Sole Oxidant: The Case Study of Costunolide;Organic Letters;2024-03-29

5. The Medicinal Moroccan Plant Cladanthus arabicus as a Prominent Source of Sesquiterpenes Cladantholide and Sintenin;AppliedChem;2024-01-25

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