Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner-Reference-Cited by-同舟云学术

Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner

Published:2022-09-08 Issue:18 Volume:65 Page:12334-12345
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dong Guangping¹^ORCID,Deng Youchao¹,Yasgar Adam²^ORCID,Yadav Ravi³,Talley Daniel²,Zakharov Alexey V.²^ORCID,Jain Sankalp²,Rai Ganesha²^ORCID,Noinaj Nicholas³,Simeonov Anton²,Huang Rong¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States

2. National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States

3. Department of Biological Sciences, Markey Center for Structural Biology, and the Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana 47907, United States

Funder

National Center for Advancing Translational Sciences

National Cancer Institute

Purdue University, Department of Medicinal Chemistry and Molecular Pharmacology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01050

Reference35 articles.

1. Protein Methyltransferases: A Distinct, Diverse, and Dynamic Family of Enzymes