Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on α-Hydroxy-β-amino Acid Derivatives of Bestatin-Reference-Cited by-同舟云学术

Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on α-Hydroxy-β-amino Acid Derivatives of Bestatin

Published:2022-07-14 Issue:14 Volume:65 Page:10098-10117
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Vourloumis Dionisios¹,Mavridis Ioannis¹,Athanasoulis Alexandros¹,Temponeras Ioannis¹²,Koumantou Despoina¹,Giastas Petros³,Mpakali Anastasia¹⁴^ORCID,Magrioti Victoria⁴,Leib Jacqueline⁵,van Endert Peter⁵⁶,Stratikos Efstratios¹⁴^ORCID,Papakyriakou Athanasios¹^ORCID

Affiliation:

1. National Centre for Scientific Research “Demokritos”, Ag. Paraskevi, GR-15341 Athens, Greece

2. Department of Pharmacy, University of Patras, 26504 Patra, Greece

3. Department of Biotechnology, Agricultural University of Athens, GR-11855 Athens, Greece

4. Department of Chemistry, National and Kapodistrian University of Athens, GR-15784 Athens, Greece

5. Université Paris Cité, INSERM, CNRS, Institut Necker Enfants Malades, F-75015 Paris, France

6. Service Immunologie Biologique, AP-HP, Hôpital Universitaire Necker-Enfants Malades, F-75015 Paris, France

Funder

Agence Nationale de la Recherche

European Regional Development Fund

Fondation pour la Recherche M?dicale

Hellenic Foundation for Research and Innovation

H2020 Research Infrastructures

Greece

Operational Programme Competitiveness, Entrepreneurship and Innovation

National Center for Scientific Research Demokritos

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00904

Reference69 articles.

1. M1 aminopeptidases as drug targets: broad applications or therapeutic niche?

2. Modulators of hERAP2 discovered by high-throughput screening

3. Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1

4. Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis and antitumor activity of new flavonoid hybrid peptidomimetics;Journal of Molecular Structure;2025-01

2. Stabilization of the open conformation οf insulin‐regulated aminopeptidase by a novel substrate‐selective small‐molecule inhibitor;Protein Science;2024-08-21

3. ERAP Inhibitors in Autoimmunity and Immuno-Oncology: Medicinal Chemistry Insights;Journal of Medicinal Chemistry;2024-07-16

4. Stabilization of the open conformation of Insulin-Regulated Aminopeptidase by a novel substrate-selective small molecule inhibitor;2024-06-05

5. The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds;International Journal of Molecular Sciences;2024-04-06