CJ2: A Novel Potent Platinum(IV) Prodrug Enhances Chemo-Immunotherapy by Facilitating PD-L1 Degradation in the Cytoplasm and Cytomembrane

Author:

Fan Renming12,Deng Aohua12,Qi Bing3,Zhang Shuo4,Sang Ruoxi12,Luo Lanxin5,Gou Jiakui4,Liu Yongqing4,Lin Ruizhuo12,Zhao Minggao5,Liu Yang4ORCID,Yang Le5,Cheng Maosheng4ORCID,Wei Gaofei12ORCID

Affiliation:

1. Research & Development Institute of Northwestern Polytechnical University, Shenzhen, Guangdong518057, P. R. China

2. Xi’an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, Xi’an, Shaanxi710072, P. R. China

3. Institute of Oncology, The Second Affiliated Hospital, Xi’an Medical University, Xi’an, Shaanxi710038, P.R. China

4. Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang110016, P. R. China

5. Precision Pharmacy & Drug Development Center, Department of Pharmacy, Tangdu Hospital, Air Force Military Medical University, Xi’an, 710038Shaanxi, P. R. China

Funder

Ministry of Education of the People's Republic of China

Science and Technology Foundation of Shenzhen City

National Natural Science Foundation of China

Innovation Capability Support Program of Shaanxi

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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