Small Molecules Targeting the RNA-Binding Protein HuR Inhibit Tumor Growth in Xenografts-Reference-Cited by-同舟云学术

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Small Molecules Targeting the RNA-Binding Protein HuR Inhibit Tumor Growth in Xenografts

Published:2023-01-23 Issue:3 Volume:66 Page:2032-2053
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wu Xiaoqing,Ramesh Remya¹,Wang Jinan^ORCID,Zheng Youguang²,Armaly Ahlam M.¹,Wei Lanjing,Xing Minli,Roy Sudeshna¹^ORCID,Lan Lan,Gao Fei Philip,Miao Yinglong^ORCID,Xu Liang³,Aubé Jeffrey¹^ORCID

Affiliation:

1. Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, The University of North Carolina, Chapel Hill, North Carolina 27599, United States

2. School of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China

3. Department of Radiation Oncology, The University of Kansas Medical Center, Kansas City, Kansas 66160, United States

Funder

National Cancer Institute

Kansas Bioscience Authority

U.S. Department of Defense

Susan G. Komen

Midwest Biomedical Accelerator Consortium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01723

Reference55 articles.

1. RNA-binding proteins and post-transcriptional gene regulation

2. HuR function in disease

3. Posttranslational control of HuR function

4. Diverse molecular functions of Hu proteins

5. Posttranscriptional regulation of cancer traits by HuR

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1. Fibroblast-Specific Depletion of Human Antigen R Alleviates Myocardial Fibrosis Induced by Cardiac Stress;JACC: Basic to Translational Science;2024-06

2. RNA-binding proteins in breast cancer: Biological implications and therapeutic opportunities;Critical Reviews in Oncology/Hematology;2024-03

3. Small molecule inhibition of RNA binding proteins in haematologic cancer;RNA Biology;2024-02-08

4. Using the structural diversity of RNA: protein interfaces to selectively target RNA with small molecules in cells: methods and perspectives;Frontiers in Molecular Biosciences;2023-11-16

5. Targeting the RNA-Binding Protein HuR in Cancer;Cancer Research;2023-09-08

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