Synthetic Strategies for Improving Solubility: Optimization of Novel Pyrazolo[1,5-<i>a</i>]pyrimidine CFTR Activator That Ameliorates Dry Eye Disease-Reference-Cited by-同舟云学术

Synthetic Strategies for Improving Solubility: Optimization of Novel Pyrazolo[1,5-a]pyrimidine CFTR Activator That Ameliorates Dry Eye Disease

Published:2022-12-27 Issue:1 Volume:66 Page:413-434
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kim Bo Yi¹,Oh Changmok²,Jeon Dongkyu³,Jun Ikhyun¹,Lee Ho K.³^ORCID,Kim Bo-Rahm¹,Park Jinhong³,Seo Kyoung Yul¹,Kim Kyeong-A²,Lim Dami²,Lee Seolhee²,Lee Jooyun²,Yoon Hongchul²,Kim Tae-im¹,Namkung Wan³^ORCID

Affiliation:

1. The Institute of Vision Research, Department of Ophthalmology, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemungu, Seoul 03722, Korea

2. Research Laboratories, ILDONG Pharmaceutical Co., Ltd., 20, Samsung 1-ro 1-gil, Hwaseong 18449, Korea

3. College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea

Funder

National Research Foundation of Korea

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01382

Reference31 articles.

1. Impact of Dry Eye Syndrome on Vision-Related Quality of Life