Design and Synthesis of Orexin 1 Receptor-Selective Agonists-Reference-Cited by-同舟云学术

Design and Synthesis of Orexin 1 Receptor-Selective Agonists

Published:2023-04-12 Issue:8 Volume:66 Page:5453-5464
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Iio Keita¹²^ORCID,Hashimoto Kao¹³,Nagumo Yasuyuki¹,Amezawa Mao¹²,Hasegawa Taisei¹²,Yamamoto Naoshi¹,Kutsumura Noriki¹²³^ORCID,Takeuchi Katsuhiko⁴^ORCID,Ishikawa Yukiko¹,Yamamoto Hikari¹³,Tokuda Akihisa¹³,Sato Tetsu⁵,Uchida Yasuo⁵^ORCID,Inoue Asuka⁵^ORCID,Tanimura Ryuji¹⁶,Yanagisawa Masashi¹⁷⁸,Nagase Hiroshi¹²^ORCID,Saitoh Tsuyoshi¹³^ORCID

Affiliation:

1. International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan

2. Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan

3. Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan

4. National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan

5. Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan

6. Open Innovation Institute, Kyoto University, Yoshida-honmachi, Sakyo-ku, Kyoto 606-8501, Japan

7. R&D Center for Frontiers of Mirai in Policy and Technology (F-MIRAI), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan

8. Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas TX75390, United States

Funder

Ministry of Education, Culture, Sports, Science and Technology

Collaborative research between the University of Tsukuba and the Toyota Motor Corporation

Japan Agency for Medical Research and Development

Japan Foundation for Applied Enzymology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01773

Reference42 articles.

1. Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior

2. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

3. Differential expression of orexin receptors 1 and 2 in the rat brain

4. The role of orexin in motivated behaviours

5. The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

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