Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer’s Disease

Author:

Turgutalp Bengisu12ORCID,Bhattarai Prabesh23,Ercetin Tugba4,Luise Chiara5,Reis Rengin67,Gurdal Enise Ece18ORCID,Isaak Andreas9,Biriken Derya210,Dinter Elisabeth211,Sipahi Hande6,Schepmann Dirk12,Junker Anna9,Wünsch Bernhard12ORCID,Sippl Wolfgang5ORCID,Gulcan Hayrettin Ozan4,Kizil Caghan23,Yarim Mine1

Affiliation:

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yeditepe University, 34755 Istanbul, Turkey

2. German Centre for Neurodegenerative Diseases (DZNE), Helmholtz Association, 01307 Dresden, Germany

3. Department of Neurology, Columbia University Irving Medical Center, 10032 New York, United States

4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Eastern Mediterranean University, TRNC, via Mersin 10, 99628 Famagusta, Turkey

5. Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-Universität Halle-Wittenberg, 6099 Halle (Saale), Germany

6. Department of Toxicology, Faculty of Pharmacy, Yeditepe University, 34755 Istanbul, Turkey

7. Department of Toxicology, Faculty of Pharmacy, Acibadem Mehmet Ali Aydinlar University, 34758 Istanbul, Turkey

8. Institute of Chemistry, Martin-Luther-Universität Halle-Wittenberg, 06120 Halle, Germany

9. European Institute for Molecular Imaging (EIMI), der Westfälischen Wilhelms-Universität, D-48149 Münster, Germany

10. Department of Medical Microbiology, Ankara University Faculty of Medicine, 06620 Ankara, Turkey

11. Department of Neurology, University Clinic, TU Dresden, 01307 Dresden, Germany

12. Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, D-48149 Münster, Germany

Funder

European Commission

T??rkiye Bilimsel ve Teknolojik Arastirma Kurumu

Helmholtz Association

Deutsches Zentrum f??r Neurodegenerative Erkrankungen

Clinician Scientist program Else Kr??ner Research College TU Dresden

Schaefer Research Scholars Award

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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