Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT)-Reference-Cited by-同舟云学术

Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT)

Published:2022-08-22 Issue:17 Volume:65 Page:11776-11787
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Koester Dennis C.¹^ORCID,Marx Vanessa M.¹,Williams Sarah¹,Jiricek Jan¹,Dauphinais Maxime¹,René Olivier¹,Miller Sarah L.¹,Zhang Lei¹,Patra Debjani²,Chen Yen-Liang³,Cheung Harry³,Gable Jonathan³,Lakshminarayana Suresh B.⁴,Osborne Colin⁵,Galarneau Jean-Rene⁶,Kulkarni Upendra⁷,Richmond Wendy⁸,Bretz Angela⁸^ORCID,Xiao Linda⁹,Supek Frantisek¹⁰,Wiesmann Christian¹¹,Honnappa Srinivas¹¹,Be Celine¹¹,Mäser Pascal¹²¹³^ORCID,Kaiser Marcel¹²¹³,Ritchie Ryan¹⁴,Barrett Michael P.¹⁴,Diagana Thierry T.²,Sarko Christopher¹,Rao Srinivasa P. S.²^ORCID

Affiliation:

1. Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States

2. Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States

3. Lead Discovery, Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States

4. Pharmacokinetic Sciences, Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States

5. Pharmacokinetic Sciences, Pharmacology and Comparative Medicine, Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States

6. Preclinical Safety, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States

7. Chemical and Pharmaceutical Profiling, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States

8. Global Discovery Chemistry, Novartis Institutes for Biomedical Research, San Diego, California 92121, United States

9. Pharmacology, Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States

10. Novartis Institutes for Biomedical Research, San Diego, California 92121, United States

11. Novartis Institutes for Biomedical Research, 4056 Basel, Switzerland

12. Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123 Allschwil, Switzerland

13. University of Basel, CH 4000 Basel, Switzerland

14. University of Glasgow, University Place, Glasgow G12 8TA, U.K.

Funder

Wellcome Trust

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00791

Reference39 articles.

1. Human African trypanosomiasis

2. Human African trypanosomiasis

3. World Health Organization, Fact Sheet, January 10, 2022, https://www.who.int/news-room/fact-sheets/detail/trypanosomiasis-human-african-(sleeping-sickness).

4. Center for Disease Control and Prevention, CDC website, https://www.cdc.gov/parasites/sleepingsickness/index.html.

5. Parasite development and host responses during the establishment ofTrypanosoma bruceiinfection transmitted by tsetse fly

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