Improving Drug Delivery While Tailoring Prodrug Activation to Modulate Cmax and Cmin by Optimization of (Carbonyl)oxyalkyl Linker-Based Prodrugs of Atazanavir-Reference-Cited by-同舟云学术

Improving Drug Delivery While Tailoring Prodrug Activation to Modulate C_max and C_min by Optimization of (Carbonyl)oxyalkyl Linker-Based Prodrugs of Atazanavir

Published:2022-08-11 Issue:16 Volume:65 Page:11150-11176
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

A. M. Subbaiah Murugaiah¹^ORCID,Subramani Lakshumanan¹,Ramar Thangeswaran¹,Desai Salil²,Sinha Sarmistha³,Mandlekar Sandhya³,Kadow John F.⁴,Jenkins Susan⁵,Krystal Mark⁶,Subramanian Murali³,Sridhar Srikanth²,Padmanabhan Shweta³,Bhutani Priyadeep³,Arla Rambabu³,Meanwell Nicholas A.⁴^ORCID

Affiliation:

1. Department of Medicinal Chemistry (Prodrug Group), Biocon-Bristol Myers Squibb Research and Development Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, India

2. Department of Biopharmaceutics, Biocon-Bristol Myers Squibb Research and Development Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, India

3. Department of Pharmaceutical Candidate Optimization, Biocon-Bristol Myers Squibb Research and Development Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, India

4. Department of Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States

5. Department of Pharmaceutical Candidate Optimization, Bristol Myers Squibb Research and Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States

6. Department of Virology, Bristol Myers Squibb Research and Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00632

Reference37 articles.

1. Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS

2. Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults

3. Cobicistat Versus Ritonavir: Similar Pharmacokinetic Enhancers But Some Important Differences

4. Atazanavir sulfate + cobicistat for the treatment of HIV infection

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