A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Assay Identifies Nilotinib as an Inhibitor of Inflammation in Acute Myeloid Leukemia

Author:

Marín-Rubio José Luis1ORCID,Peltier-Heap Rachel E.1,Dueñas Maria Emilia1,Heunis Tiaan12,Dannoura Abeer1,Inns Joseph1,Scott Jonathan3,Simpson A. John34,Blair Helen J.5,Heidenreich Olaf5,Allan James M.5,Watt Jessica E.6ORCID,Martin Mathew P.6,Saxty Barbara7,Trost Matthias1ORCID

Affiliation:

1. Laboratory for Biological Mass Spectrometry, Biosciences Institute, Newcastle University, Newcastle-upon-Tyne NE2 4HH, UK

2. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK

3. Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne NE2 4HH, UK

4. Respiratory Medicine Unit, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK

5. Translational and Clinical Research Institute, Newcastle University, Herschel Building, Level 6, Brewery Lane, Newcastle upon Tyne NE1 7RU, UK

6. Newcastle Cancer Centre, Northern Institute for Cancer Research, Medical School, Newcastle University, Paul O’Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK

7. LifeArc, SBC Open Innovation Campus, Stevenage SG1 2FX, UK

Funder

H2020 Marie Sklodowska-Curie Actions

Wellcome Trust

Biotechnology and Biological Sciences Research Council

Newcastle University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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